Infectious Diseases and HIV Conference

Gene expression is probably one of the very basic biological processes by which genetic information is translated into functional proteins that influences cellular behavior, health, and disease.

In this session, mechanisms of gene expression, regulatory processes, and what implications they bring will be explored to understand infectious diseases and other health conditions really. This includes several stages of gene expression, transcription and translation.

Transcription is essentially the process in which RNA polymerase transcribes DNA into messenger RNA (mRNA). However, translation is a process wherein ribosomes synthesize proteins based on an mRNA sequence. The whole process will be taken up in this session with emphasis placed on important regulators like promoters, enhancers, and transcription factors, which orchestrate gene expression. It also deals with post-transcriptional modifications such as RNA splicing, capping, and polyadenylation.Epigenetic modifications such as DNA methylation and histone modification contribute significantly to regulation of gene expression without altering the DNA sequence.

In this session, you will learn about the concept of epigenetics with regard to the significance of gene regulation, the difference in types of cells, and responsiveness to environmental signals.

In this session, you will learn how epigenetic alterations result in alterations in gene expression profiles that are associated with diseases such as cancers and infectious diseases. Infective agents greatly influence the expression of host genes, which then may impair and further affect the immune response and the disease outcome.

This session will consider how pathogens, such as viruses, bacteria, or parasites, exploit host cellular machinery for survival and multiplication. Attendees will understand the consequences of altered gene expression that occurs with infections and its significance for the planning of therapeutic strategies. Gene expression research is absolutely at the heart of medicine because it is enabling us to target the medical treatment and tailor it to a given individual's needs.

In the context of today, this meeting will focus on how gene expression profiling guides the diagnosis and prognosis in an array of diseases, thereby potentiating more appropriate treatment decisions and better patient outcomes. We will also be considering the potential opened up by gene-editing technologies such as CRISPR-Cas9 to manipulate gene expression for therapy.

The session will cover the future directions of gene expression research which includes newly emerging high-throughput sequencing technologies, single-cell transcriptomics, and integrative approaches to study regulation in gene expression.

It will present insights regarding the continuing challenges as well as opportunities in understanding the complexity of the relationship between gene expression and health versus disease.